According to Afghan's TOLO News, the explosive laden ambulance was detonated between two checkpoints outside the old Ministry of Interior building close to Sedarat Square, close to well known Chicken Street.
Ambulances are present at the scene.
A huge plume of smoke could also be seen rising above the city.
This bombing is the latest in a string of deadly attacks across Afghanistan in the past week.
Earlier this week on Wednesday, 'Save The Children' organisation in Afghan's Jalalabad city, Nangarhar province attacked.
Last Saturday, the Taliban gunmen raided a luxury hotel in Kabul, killing at least 22 people, mostly foreigners. (ANI)