Exercise helps cut pain from nerve damage

   Jun 2, 4:59 pm

Washington, June 2 (ANI): Exercising helps in lessening the pain related to nerve damage by reducing levels of certain inflammation-promoting factors, a new study suggests.

The results support exercise as a potentially useful nondrug treatment for neuropathic pain, and suggest that it may work by reducing inflammation-promoting substances called cytokines.

The lead author of the study is Yu-Wen Chen, PhD, of China Medical University, Taichung, Taiwan.

Neuropathic pain is a common and difficult-to-treat type of pain caused by nerve damage, seen in patients with trauma, diabetes, and other conditions. Phantom limb pain after amputation is an example of neuropathic pain.

Dr Chen and colleagues examined the effects of exercise on neuropathic pain induced by sciatic nerve injury in rats.

After nerve injury, some animals performed progressive exercise-either swimming or treadmill running-over a few weeks.

The researchers assessed the effects of exercise on neuropathic pain severity by monitoring observable pain behaviors.

The results suggested significant reductions in neuropathic pain in rats assigned to swimming or treadmill running. Exercise reduced abnormal responses to temperature and pressure-both characteristic of neuropathic pain.

Exercise also led to reduced expression of inflammation-promoting cytokines in sciatic nerve tissue-specifically, tumor necrosis factor-alpha and interleukin-1-beta. That was consistent with previous studies suggesting that inflammation and pro-inflammatory cytokines play a role in the development of neuropathic pain in response to nerve injury.

Exercise also led to increased expression of a protein, called heat shock protein-27, which may have contributed to the reductions in cytokine expression.

Neuropathic pain causes burning pain and numbness that is not controlled by conventional pain medications. Antidepressant and antiepileptic drugs may be helpful, but have significant side effects.

Exercise is commonly recommended for patients with various types of chronic pain, but there are conflicting data as to whether it is helpful in neuropathic pain.

The new results support the benefits of exercise in reducing neuropathic pain, though not eliminating it completely. In the experiments, exercise reduced abnormal pain responses by 30 to 50 percent.

The study also adds new evidence that inflammation contributes to the development of neuropathic pain, including the possible roles of pro-inflammatory cytokines. The results provide support for exercise as a helpful, nondrug therapy for neuropathic pain-potentially reducing the need for medications and resulting side effects.he study is published in the official journal of the International Anesthesia Research Society (IARS), Anesthesia and Analgesia. (ANI)

World's oldest woman's blood hints at lifespan limits Apr 24, 2:30 pm
London, Apr.24 (ANI): The world's oldest woman's blood analysis has concluded that lifespan of humans might ultimately be limited by the capacity for stem cells to keep replenishing tissues day in day out.
Full Story
Climate change likely to make climbing Everest riskier, less predictable Apr 24, 1:51 pm
Washington, Apr 24 (ANI): Scientists have claimed that climbing Mount Everest is becoming less predictable and possibly more dangerous, as climate change brings warmer temperatures that may eat through the ice and snow on the highest peak in the world.
Full Story
How ravens maintain their social relations Apr 24, 1:14 pm
Washington, Apr 24 (ANI): A new study has found that like many social mammals, ravens form different types of social relationships - they may be friends, kin, or partners and they also form strict dominance relations.
Full Story
Microbes help understand evolution of human language Apr 24, 12:23 pm
Washington, Apr 24 (ANI): Researchers have discovered how a species of pond life communicates, providing insight into the evolution of human language.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY