Molecular 'tweezers' may help prevent progression of Parkinson's

   Mar 3, 5:26 pm

Washington, Mar 3 (ANI): While the exact cause behind Parkinson's disease is still not known, evidence points to one particular culprit: a protein called a-synuclein.

The protein, which has been found to be common to all patients with Parkinson's - a disorder of the nervous system that affects movement and worsens over time - is thought to be a pathway to the disease when it binds together in "clumps," or aggregates, and becomes toxic, killing the brain's neurons.

Now, scientists at UCLA have found a way to prevent these clumps from forming, prevent their toxicity and even break up existing aggregates.

UCLA professor of neurology Jeff Bronstein and UCLA associate professor of neurology Gal Bitan, along with their colleagues, report the development of a novel compound known as a "molecular tweezer," which in a living animal model blocked a-synuclein aggregates from forming, stopped the aggregates' toxicity and, further, reversed aggregates in the brain that had already formed.

And the tweezers accomplished this without interfering with normal brain function.

Bronstein collaborated with Bitan, who had been working with a particular molecular tweezer he had developed called CLR01. Molecular tweezers are complex molecular compounds that are capable of binding to other proteins.

Shaped like the letter "C," these compounds wrap around chains of lysine, a basic amino acid that is a constituent of most proteins.

Working first in cell cultures, the researchers found that CLR01 was able to prevent a-synuclein from forming aggregates, prevent toxicity and even break up existing aggregates.

"The most surprising aspect of the work," Bronstein said, "is that despite the ability of the compound to bind to many proteins, it did not show toxicity or side effects to normal, functioning brain cells."

"We call this unique mechanism 'process-specific,' rather than the common protein-specific inhibition," Bitan added, meaning the compound only attacked the targeted aggregates and nothing else.

The researchers next tried their tweezers in a living animal, the zebrafish, a tropical freshwater fish commonly found in aquariums.

Using a transgenic zebrafish model for Parkinson's disease, the researchers added CLR01 and used fluorescent proteins to track the tweezer's effect on the aggregations.

They found that, just as in cell cultures, CLR01 prevented a-synuclein aggregation and neuronal death, thus stopping the progression of the disorder in the living animal model.

Being able to prevent a-synuclein from aggregating, prevent toxicity and break up existing aggregates is a very encouraging result, but still, at the end of the day, "we've only stopped Parkinson's in zebrafish," Bronstein said.

"Nonetheless," he said, "all of these benefits of CLR01 were found without any evidence of toxicity."

"And taken together, CLR01 holds great promise as a new drug that can slow or stop the progression of Parkinson's and related disorders. This takes us one step closer to a cure," he added.

The research appears in the current online edition of the journal Neurotherapeutics. (ANI)

India demonstrates capability of launching Geosynchronous satellite Jul 30, 6:04 pm
New Delhi, July 30 (ANI): India has demonstrated the capability of launching 1.4 ton class of satellites using Polar Satellite Launch Vehicle (PSLV) and 2 ton class of satellites using Geosynchronous Satellite Launch Vehicle (GSLV) Mk II to Geosynchronous Transfer Orbit (GTO).
Full Story
Blocking this gene cuts excessive fat, finds study Jul 30, 12:55 pm
Washington DC, July 30 (ANI): Scientists have found that it is possible to reduce fat by blocking the expression of a certain gene in patients.
Full Story
ICAR lab artificially breeds milkfish for first time in India Jul 29, 4:28 pm
Chennai, July 29 (ANI): For the first time in India, Chennai-based Central Institute of Brackishwater Aquaculture (CIBA) succeeded in artificially breeding milkfish (Chanos chanos), locally known as "Paal Kendai" or "Poo Meen". Milkfish has the ability to grow in brackish water, seawater and even adapts to freshwater conditions.
Full Story
8-year-old receives world's first double hand transplant Jul 29, 2:22 pm
Washington DC, July 29 (ANI): Surgeons from the Children's Hospital of Philadelphia and Penn Medicine have completed the world's first double hand transplant on an 8-year-old child.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY